Beilstein J. Org. Chem.2023,19, 998–1007, doi:10.3762/bjoc.19.75
, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, 518055, China 10.3762/bjoc.19.75 Abstract Five new eudesmane-type sesquiterpenoids (aquisinenoids F–J (1–5)) and five known compounds (6–10) were isolated from the agarwood of Aquilariasinensis. Their structures, including
revealed the structure–activity relationships (SAR).
Keywords: agarwood; Aquilariasinensis; SAR studies; sesquiterpenoids; Introduction
Agarwood is the resinous wood of the Aquilaria species of the Thymelaeaceae family [1]. It is a precious traditional Chinese medicinal material and a kind of natural
deep insight into novel molecules with effective bioactivities from agarwood. Therefore, the continued study of Aquilariasinensis has led to the isolation of ten sesquiterpenoids, including five new eudesmane-type sesquiterpenoids (Figure 1). Herein, we describe the isolation, structural elucidation